Appendicular Lean Mass

8K1K13

Appendicular lean mass is the measurable bulk of muscle in your arms and legs—your body’s built‑in strength reservoir that powers everything from lifting groceries to climbing stairs, and subtly shifts with age, activity, or injury. Research shows that variations near genes regulating muscle development (like MSTN and...

SNP Stats

Mapped
1,068
Positive
537 (50.3%)
Negative
531 (49.7%)

Genome Matching (1)

Public Results (7,972)

Connected Traits (1)

appendicular lean mass

Appendicular lean mass (EFO_0004980) is the total mass of lean tissue in the arms and legs, typically assessed by imaging methods such as DXA. It is a trait used to evaluate mus...

EFO_0004980

0 evidence1K SNPs1 traits0 studies0 positive · 0 negative

Connected Studies (3)

The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study.

PubMed 33097823

0 evidence700 SNPs1 traits1 studies0 positive · 0 negative

Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2.

PubMed 31761296

0 evidence447 SNPs1 traits1 studies0 positive · 0 negative

Gene polymorphisms associated with heterogeneity and senescence characteristics of sarcopenia in chronic obstructive pulmonary disease.

PubMed 36856146

0 evidence20 SNPs5 traits1 studies0 positive · 0 negative

Connected Genes (667)

RBFOX1

RNA binding fox-1 homolog 1

The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regul...

1 evidence409 SNPs0 traits0 studies0 positive · 1 negative

DLEU1

deleted in lymphocytic leukemia 1

8 evidence368 SNPs0 traits0 studies3 positive · 5 negative

BNC2

basonuclin zinc finger protein 2

This gene encodes a conserved zinc finger protein. The encoded protein functions in skin color saturation. Mutations in this gene are associated with facial pigmented spots. Thi...

2 evidence297 SNPs0 traits0 studies1 positive · 1 negative

PPP1R3B-DT

PPP1R3B divergent transcript

1 evidence242 SNPs0 traits0 studies0 positive · 1 negative

SOX5

SRY-box transcription factor 5

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the c...

1 evidence240 SNPs0 traits0 studies0 positive · 1 negative

Connected SNPs (1,068)

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