Open phenotype catalog
Browse public phenotypes.
Explore the Genodex public phenotype catalog and preview public result context from public genomes.
Showing 1-30 of 120 public phenotypes
Cognitive Function Measurement
Cognitive function measurement captures how well your brain performs tasks like memory, reasoning, attention, and problem-solving â core abilities that shape learning and daily decision-making. Research shows that variations near genes involved in synaptic plasticity, neurotransmission, and brain development (such asâŻCOMT,âŻBDNF, andâŻAPOE) can influence individual differences in cognitive performance. Cognitive abilities vary widely across the population, with heritability estimates ranging from 50â80%, reflecting a strong genetic component alongside environmental factors like education and lifestyle.
Eye Color
Eye color is your visible genetic signature â determined by the amount and type of pigments in the iris, giving rise to shades from blue and green to brown and hazel. Research shows that variations near genes involved in melanin production and iris development (likeâŻOCA2,âŻHERC2, andâŻTYR) play a major role in determining eye color. Eye color distribution varies globally, with high heritability estimates often above 90%, making it one of the most strongly genetically determined human traits.
Hair Color
Hair color is a visible genetic trait determined by the type and amount of melanin pigment in your hair, resulting in a range of shades from black and brown to blonde and red. Research shows that variations near genes involved in pigmentation (likeâŻMC1R,âŻOCA2, andâŻTYRP1) play a major role in determining hair color diversity. Hair color has high heritability â often above 80% â making it one of the most strongly genetically influenced physical traits.
Skin Pigmentation
Our skin tone is a visible echo of our ancestorsâ environments. Itâs not about beauty standards â itâs about biology, adaptation, and survival. From equatorial sun to northern twilight, human skin has evolved to strike a balance between protection from UV radiation and production of vitamin D. Embracing this diversity isnât just respectful â itâs scientifically profound. Skin pigmentation is primarily controlled by genes like MC1R, SLC24A5, OCA2, and TYR, which influence melanin production, type, and distribution within the skin. The heritability of skin pigmentation is exceptionally high, ranging from 70% to 90% across populations. Variants in SLC24A5 alone explain up to 25â38% of pigmentation differences between major continental groups.
Aggressive Behavior Quality
Aggressive behavior quality reflects the intensity, frequency, and control of aggressive responsesâranging from occasional assertiveness to patterns of hostility that affect relationships and wellbeing. Understanding these variations helps us appreciate how biology and experience shape emotional regulation and social interactions. Genetic influences on aggressive behavior quality involve variants near genes like MAOA, COMT, and SLC6A4, which regulate neurotransmitters such as serotonin and dopamine, key to mood and impulse control. Heritability estimates for aggressive behavior quality typically range from 40% to 60%, emphasizing the significant genetic contribution alongside environmental factors like childhood experiences and social environment.
Alcohol Drinking
Alcohol drinking is your social ritual turned measurable habitâwhether itâs a glass of wine with dinner or a weekend night out, it reflects a blend of culture, personal choice, and biology. Research shows that variations near genes regulating alcohol metabolism (likeâŻADH1BâŻandâŻALDH2) and those influencing reward pathways (such asâŻGABRA2) can shape individual differences in drinking behavior. Worldwide, about 43% of adults report current alcohol use, and twin studies estimate heritability of general alcohol consumption at around 40â60%, highlighting a significant genetic influence on how muchâand how oftenâyou drink.
Attention Function Measurement
Attention function measurement is your brainâs builtâin spotlight on the world, gauging how sharply you focus on a task or filter out distractionsâwhether reading a book in a noisy cafĂ© or zoning back into work after an interruption. Research shows that variations near genes regulating dopamine signaling and frontoâstriatal circuitry (likeâŻDRD4, COMT, and SLC6A3) can influence individual differences in sustained attention and distractibility. While clinically significant attention deficits (such as those seen in ADHD) affect about 5% of children, continuous measures of attention performance span the entire populationâand twin studies estimate heritability of general attentional capacity at roughly 70â80%, underscoring a strong genetic contribution.
Behavioral Disinhibition Measurement
Behavioral disinhibition measurement is your mindâs builtâin impulse gauge, tracking how often you act without thinkingâfrom blurting out comments to chasing thrillsârevealing when selfâcontrol takes a back seat to spontaneity. Research shows that variations near genes regulating inhibitory neurotransmission (likeâŻGABRA2 andâŻCHRNA5) and those affecting dopamine signaling pathways (such asâŻDRD2) can shape individual differences in disinhibitory behavior. While extreme disinhibition underlies conditions like ADHD or substanceâuse disorders (affecting roughly 5â10% of people), traitâlevel measures span the entire population, and twin studies estimate heritability of general disinhibition at around 50â60%, highlighting a significant genetic contribution.
Body Fat Percentage
Body fat percentage is your bodyâs hidden dashboard for the balance between lean tissue and stored energyârevealing whether you carry more muscle or extra padding, and offering a clearer picture of health than weight alone. Research shows that variations near genes regulating adipogenesis and energy balance (likeâŻFTO andâŻPPARG) and those influencing lipid storage and mobilization (such asâŻADIPOQ) can shape individual differences in how much body fat you carry. In healthy adults, average body fat percentage ranges roughly from 10â20% in men and 20â30% in women, and twin studies estimate heritability at aboutâŻ40â60%, highlighting a substantial genetic role in determining your bodyâs composition.
Body Height
Body height is your most visible genetic signature â shaped early in life and standing tall as a reflection of bone growth, nutrition, and inherited growth potential. Research shows that variations near genes involved in skeletal development and growth hormone pathways (likeâŻHMGA2,âŻEFEMP1, andâŻGDF5) can strongly influence final adult stature. Height is one of the most heritable human traits, with genetic factors accounting for approximately 80â90% of variation, and average adult height ranging globally from about 160âŻcm to 180âŻcm depending on population and sex.
Brain Connectivity Attribute
Brain connectivity attribute is your neural networkâs blueprintâcapturing how different regions of the brain communicate, sync, and relay information, shaping everything from memory to emotion to decisionâmaking. Research shows that variations near genes involved in synaptic structure and signaling (likeâŻCNTNAP2,âŻDISC1, andâŻNRXN1) can influence patterns of functional and structural brain connectivity. Individual differences in brain connectivity are measurable through imaging techniques like fMRI or DTI, and twin studies estimate heritability between 40â60%, highlighting a significant genetic role in shaping how your brain is wired.
Brain Volume
Brain volume is your brainâs physical footprintâmeasuring the total size of the organ that governs thought, emotion, and behavior, and offering clues about development, aging, and neurological health. Research shows that variations near genes involved in neurodevelopment and cell growth (likeâŻHMGA2,âŻMAPT, andâŻKIAA0586) can influence total brain volume as well as specific regional sizes. Average adult brain volume is about 1,200â1,500âŻcmÂł, and heritability estimates range from 70â90%, making it one of the most strongly genetically influenced traits in human biology.
Breastfeeding Duration
Breastfeeding duration reflects a complex interplay of biology, behavior, and contextâcapturing how long a mother continues nursing, shaped by milk supply, infant needs, cultural norms, and personal choice. Research shows that variations near genes involved in prolactin signaling, lactation physiology, and hormonal regulation (likeâŻOXTR,âŻPRL, andâŻESR1) can influence the ability and duration of breastfeeding. Breastfeeding duration varies widely across populations, with global averages ranging from a few weeks to over a year, and heritability estimates from twin studies falling between 40â60%, indicating a moderate genetic influence alongside strong social and environmental factors.
Cannabis Use
Cannabis use is a behavioral trait capturing whetherâand how oftenâsomeone consumes cannabis, shaped by social context, personal preference, and neurobiological sensitivity. Research shows that variations near genes involved in reward processing, impulse control, and cannabinoid signaling (likeâŻCADM2,âŻNCAM1, andâŻCNR1) can influence likelihood and frequency of cannabis use. Lifetime cannabis use is reported by 20â40% of adults in many countries, with heritability estimates ranging from 40â60%, indicating a notable genetic influence alongside strong environmental and cultural factors.
Creativity Measurement
Creativity measurement captures your brainâs ability to generate novel ideas, solve problems in unique ways, and think outside the boxâfueling innovation, art, and everyday imagination. Research shows that variations near genes involved in dopamine signaling, synaptic plasticity, and cognitive flexibility (such asâŻDRD2,âŻBDNF, andâŻCOMT) can influence individual differences in creative thinking. Creativity varies widely among individuals, with heritability estimates ranging from 30â50%, indicating both genetic and environmental factors contribute to creative potential.
Daytime Rest Measurement
Daytime rest measurement captures how often and how long you take breaks or naps during the dayâreflecting your bodyâs need to recharge and maintain alertness. Research shows that variations near genes regulating sleepâwake cycles and circadian rhythms (likeâŻPER3,âŻCLOCK, andâŻABCC9) can influence individual differences in daytime rest patterns. Daytime napping habits vary widely across cultures and individuals, with heritability estimates around 30â50%, highlighting a moderate genetic influence alongside lifestyle and environmental factors.
Energy Intake
Energy intake measures the amount of calories consumed through food and drinkâfueling your bodyâs daily activities, metabolism, and overall energy balance. Research shows that variations near genes regulating appetite, metabolism, and satiety (likeâŻFTO,âŻMC4R, andâŻLEPR) can influence individual differences in energy consumption. Daily energy intake varies widely based on age, sex, and lifestyle, with heritability estimates around 40â60%, highlighting a notable genetic contribution alongside environmental factors.
Facial Wrinkling
Facial wrinkling is your skinâs natural record of aging and environmental exposure, showing lines and creases formed by years of repeated expressions, sun damage, and collagen breakdown. Research shows that variations near genes involved in skin elasticity and collagen production (likeâŻMMP1,âŻELN, andâŻCOL1A1) can influence the extent and pattern of facial wrinkles. Wrinkling increases with age for everyone, but heritability estimates range from 30â50%, indicating that genetics plays a moderate role alongside lifestyle factors like sun exposure and smoking.
Feeling Miserable Measurement
Feeling miserable measurement captures the intensity and frequency of low mood or unhappinessâreflecting how individuals experience and process feelings of sadness, frustration, or dissatisfaction. Research shows that variations near genes involved in mood regulation and neurotransmitter systems (such asâŻSLC6A4,âŻBDNF, andâŻCRHR1) can influence susceptibility to persistent negative emotions. Prevalence of significant low mood varies, with heritability estimates around 30â50%, indicating that both genetic and environmental factors contribute to the experience of feeling miserable.
Feeling Nervous Measurement
Feeling nervous measurement captures how often and intensely individuals experience feelings of unease, worry, or anxietyâcommon emotional responses to stress or uncertain situations. Research shows that variations near genes involved in the stress response and neurotransmission (likeâŻCRHR1,âŻSLC6A4, andâŻGABRA2) can influence individual differences in nervousness and anxiety levels. Nervousness varies widely across people, with heritability estimates around 30â50%, highlighting the combined role of genetics and environment in shaping this emotional trait.
Feeling Tense Measurement
Feeling tense measurement captures how frequently and intensely individuals experience physical and mental stiffness or stressâoften manifesting as muscle tightness, restlessness, or irritability during challenging situations. Research shows that variations near genes involved in stress regulation and neurotransmitter activity (such asâŻCRHR1,âŻSLC6A4, andâŻGABRA2) can influence individual differences in tension and stress response. Tension levels vary widely across individuals, with heritability estimates around 30â50%, reflecting a blend of genetic predisposition and environmental influences like stress and lifestyle.
Fish Consumption
Fish consumption measures how often and how much fish an individual eatsâa dietary habit linked to heart health, brain function, and nutrient intake like omega-3 fatty acids. Research shows that variations near genes influencing taste preference, lipid metabolism, and dietary habits (such asâŻFADS1,âŻFADS2, andâŻCYP2A6) can affect individual differences in fish consumption. Fish consumption varies widely across populations and cultures, with heritability estimates around 30â50%, highlighting genetic and environmental factors shaping dietary choices.
Freckles
Freckles are small, concentrated spots of melanin on the skin, often appearing on sun-exposed areas and becoming more prominent with sunlight exposure. Research shows that variations near genes involved in pigmentation regulation (likeâŻMC1R,âŻTYR, andâŻASIP) strongly influence freckle formation and distribution. Freckles are more common in individuals with lighter skin tones, and heritability estimates are highâoften above 80%âmaking freckles a strongly genetically determined trait.
Guilt Measurement
Guilt measurement captures how strongly and frequently individuals experience feelings of remorse or responsibility after actions perceived as wrongâplaying a key role in social behavior and moral development. Research shows that variations near genes involved in emotional regulation and social cognition (such asâŻOXTR,âŻSLC6A4, andâŻMAOA) can influence individual differences in guilt sensitivity. Guilt sensitivity varies among individuals, with heritability estimates around 30â50%, reflecting a combination of genetic predisposition and environmental factors like upbringing and cultural norms.
Height Growth Attribute
Height growth attribute measures the rate at which an individualâs stature increases over timeâreflecting how quickly bones lengthen during childhood and adolescence. Research shows that variations near genes involved in skeletal growth and hormone regulation (likeâŻFGFR3,âŻIGF1, andâŻGHR) can influence differences in growth velocity. Growth rates vary widely among individuals, with heritability estimates around 60â80%, underscoring a strong genetic influence on how rapidly height increases during development.
Insomnia
Insomnia is the difficulty falling or staying asleep, leading to poor sleep quality and daytime fatigueâoften triggered by stress, lifestyle, or underlying health conditions. Research shows that variations near genes involved in circadian rhythm regulation and neurotransmission (likeâŻABCC9,âŻPER3, andâŻGRIA2) can influence susceptibility to insomnia. Insomnia affects about 10â30% of adults worldwide, with heritability estimates around 30â40%, highlighting a moderate genetic contribution alongside environmental and behavioral factors.
Intelligence
Intelligence captures your brainâs overall capacity for learning, reasoning, problem-solving, and adapting to new situationsâcore skills shaping everyday life and complex tasks alike. Research shows that variations near genes involved in brain development, synaptic function, and neurotransmission (such asâŻFOXP2,âŻBDNF, andâŻCOMT) can influence individual differences in intelligence. Intelligence varies widely across the population, with heritability estimates ranging from 50â80%, reflecting a strong genetic influence alongside environmental factors like education and socioeconomic status.
Irritability Measurement
Irritability measurement captures how easily and frequently an individual becomes annoyed or frustratedâreflecting emotional sensitivity to stress, discomfort, or social interactions. Research shows that variations near genes involved in emotional regulation and neurotransmitter function (such asâŻSLC6A4,âŻMAOA, andâŻCOMT) can influence individual differences in irritability. Irritability levels vary across individuals, with heritability estimates around 30â50%, highlighting a combination of genetic predisposition and environmental influences like stress and lifestyle.
Mathematical Ability
Mathematical ability measures your capacity to understand, reason with, and solve numerical problemsâskills essential for logic, calculation, and analytical thinking. Research shows that variations near genes involved in cognitive processing and brain development (likeâŻROBO1,âŻFOXP2, andâŻKIAA0319) can influence individual differences in mathematical skills. Mathematical ability varies widely among individuals, with heritability estimates ranging from 40â60%, reflecting a significant genetic influence alongside educational and environmental factors.
Memory Performance
Memory performance captures how effectively you can encode, store, and retrieve informationâshaping everything from daily recall to long-term learning. Research shows that variations near genes involved in synaptic plasticity and neural signaling (such asâŻBDNF,âŻAPOE, andâŻCOMT) can influence individual differences in memory ability. Memory capacity varies widely among individuals, with heritability estimates ranging from 40â70%, highlighting a strong genetic contribution alongside environmental influences like education and health.