Insomnia

8K3K16

Insomnia is the difficulty falling or staying asleep, leading to poor sleep quality and daytime fatigue—often triggered by stress, lifestyle, or underlying health conditions. Research shows that variations near genes involved in circadian rhythm regulation and neurotransmission (like ABCC9, PER3, and GRIA2) can influe...

SNP Stats

Mapped
2,710
Positive
1,403 (51.8%)
Negative
1,307 (48.2%)

Genome Matching (1)

Public Results (7,973)

Connected Traits (1)

insomnia

Insomnia (EFO_0004698) is a sleep disorder characterized by persistent difficulty in initiating or maintaining sleep, or experiencing non-restorative sleep, leading to impaired...

EFO_0004698

0 evidence3K SNPs1 traits0 studies0 positive · 0 negative

Connected Studies (6)

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.

PubMed 39024449

0 evidence15K SNPs829 traits1 studies0 positive · 0 negative

Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways.

PubMed 35835914

0 evidence3K SNPs1 traits1 studies0 positive · 0 negative

Participation bias in the UK Biobank distorts genetic associations and downstream analyses.

PubMed 37106081

0 evidence1K SNPs19 traits1 studies0 positive · 0 negative

Connected Genes (779)

RBFOX1

RNA binding fox-1 homolog 1

The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regul...

11 evidence409 SNPs0 traits0 studies6 positive · 5 negative

POLR1HASP

POLR1H antisense, pseudogene

2 evidence367 SNPs0 traits0 studies2 positive · 0 negative

CSMD1

CUB and Sushi multiple domains 1

Predicted to act upstream of or within several processes, including learning or memory; mammary gland branching involved in pregnancy; and reproductive structure development. Pr...

3 evidence351 SNPs0 traits0 studies0 positive · 3 negative

CADM2

cell adhesion molecule 2

This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like d...

1 evidence319 SNPs0 traits0 studies1 positive · 0 negative

PTPRD

protein tyrosine phosphatase receptor type D

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular proce...

12 evidence283 SNPs0 traits0 studies7 positive · 5 negative

Connected SNPs (2,710)

rs11039216

SLC39A13-AS1, SPI1

chr11additiveAlt T1.000

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