Neuroticism Measurement

8K2K117

Neuroticism measurement captures a personality trait characterized by emotional instability, anxiety, and a tendency toward negative feelings like worry and irritability. Research shows that variations near genes involved in neurotransmission and stress response (such as SLC6A4, CRHR1, and BDNF) can influence individu...

SNP Stats

Mapped
1,570
Positive
820 (52.2%)
Negative
750 (47.8%)

Genome Matching (1)

Public Results (7,973)

Connected Traits (1)

neuroticism measurement

Neuroticism measurement (EFO_0007660) quantifies the personality trait of neuroticism, characterized by emotional instability, anxiety, and negative affectivity. It is commonly...

EFO_0007660

0 evidence2K SNPs1 traits0 studies0 positive · 0 negative

Connected Studies (17)

Item-level analyses reveal genetic heterogeneity in neuroticism.

PubMed 29500382

0 evidence662 SNPs12 traits1 studies0 positive · 0 negative

Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

PubMed 29942085

0 evidence639 SNPs4 traits1 studies0 positive · 0 negative

Multivariate genome-wide analyses of the well-being spectrum.

PubMed 30643256

0 evidence521 SNPs3 traits1 studies0 positive · 0 negative

Connected Genes (424)

HLA-F-AS1

HLA-F antisense RNA 1

1 evidence512 SNPs0 traits0 studies1 positive · 0 negative

RBFOX1

RNA binding fox-1 homolog 1

The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regul...

11 evidence409 SNPs0 traits0 studies7 positive · 4 negative

CADM2

cell adhesion molecule 2

This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like d...

4 evidence319 SNPs0 traits0 studies2 positive · 2 negative

DCC

DCC netrin 1 receptor

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal...

16 evidence268 SNPs0 traits0 studies9 positive · 7 negative

LINC01122

long intergenic non-protein coding RNA 1122

5 evidence262 SNPs0 traits0 studies2 positive · 3 negative

Connected SNPs (1,570)

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