Pain Perception

8K4226

Pain is your body’s warning system signaling injury, inflammation, or potential harm—ranging from sharp acute sensations to persistent chronic discomfort that affects daily life. Research shows that variations near genes involved in pain perception and nerve signaling (like SCN9A, OPRM1, and TRPV1) can influence indiv...

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SNP Stats

Mapped
42
Positive
24 (57.1%)
Negative
18 (42.9%)

Genome Matching (1)

Public Results (7,973)

NA21144

1000 Genomes Project · South Asian · Human

39 of 42 SNPs with zeta at 7.034

99.9

NA21143

1000 Genomes Project · South Asian · Human

39 of 42 SNPs with zeta at 7.034

99.9

NA21130

1000 Genomes Project · South Asian · Human

39 of 42 SNPs with zeta at 7.034

99.9

NA21117

1000 Genomes Project · South Asian · Human

39 of 42 SNPs with zeta at 7.034

99.9

NA21116

1000 Genomes Project · South Asian · Human

39 of 42 SNPs with zeta at 7.034

99.9

NA21114

1000 Genomes Project · South Asian · Human

39 of 42 SNPs with zeta at 7.034

99.9

NA21107

1000 Genomes Project · South Asian · Human

39 of 42 SNPs with zeta at 7.034

99.9

Connected Traits (2)

pain

EFO_0003843

0 evidence25 SNPs1 traits0 studies0 positive · 0 negative

pain measurement

EFO_0010639

0 evidence19 SNPs1 traits0 studies0 positive · 0 negative

Connected Studies (6)

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.

PubMed 39024449

0 evidence15K SNPs829 traits1 studies0 positive · 0 negative

Adolescent anxiety and pain problems: A joint, genome-wide investigation and pathway-based analysis.

PubMed 37146008

0 evidence27 SNPs2 traits1 studies0 positive · 0 negative

A genome-wide association study of European advanced cancer patients treated with opioids identifies regulatory variants on chromosome 20 associated with pain intensity.

PubMed 39629963

0 evidence19 SNPs2 traits1 studies0 positive · 0 negative

Connected Genes (23)

TENM2

teneurin transmembrane protein 2

Enables cell adhesion molecule binding activity and signaling receptor binding activity. Involved in several processes, including calcium-mediated signaling using intracellular...

1 evidence167 SNPs0 traits0 studies0 positive · 1 negative

LPP

LIM domain containing preferred translocation partner in lipoma

This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protei...

1 evidence155 SNPs0 traits0 studies0 positive · 1 negative

LUZP2

leucine zipper protein 2

This gene encodes a leucine zipper protein. This protein is deleted in some patients with Wilms tumor-Aniridia-Genitourinary anomalies-mental Retardation (WAGR) syndrome. Altern...

1 evidence80 SNPs0 traits0 studies1 positive · 0 negative

DRAIC

downregulated RNA in cancer, inhibitor of cell invasion and migration

1 evidence68 SNPs0 traits0 studies0 positive · 1 negative

STEAP1B

STEAP family member 1B

Predicted to be integral component of membrane. Predicted to be active in endosome and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

2 evidence62 SNPs0 traits0 studies0 positive · 2 negative

Connected SNPs (42)

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