Sex hormone-binding globulin

8K2K116

Sex hormone-binding globulin (SHBG) is like a molecular chaperone—it binds to sex hormones like testosterone and estrogen, helping regulate their access to tissues and cells. It plays a subtle but crucial role in balancing mood, energy, libido, and even metabolic function. When SHBG levels are off, people may feel symp...

SNP Stats

Mapped
1,798
Positive
1,256 (69.9%)
Negative
542 (30.1%)

Genome Matching (1)

Public Results (7,972)

Connected Traits (1)

sex hormone-binding globulin measurement

Sex hormone-binding globulin measurement (EFO_0004696) quantifies the concentration of SHBG in blood, usually expressed in nmol/L. SHBG regulates the bioavailability of sex horm...

EFO_0004696

0 evidence2K SNPs1 traits0 studies0 positive · 0 negative

Connected Studies (16)

A scalable variational inference approach for increased mixed-model association power.

PubMed 39789286

0 evidence46K SNPs2K traits1 studies0 positive · 0 negative

Genetics of 35 blood and urine biomarkers in the UK Biobank.

PubMed 33462484

0 evidence6K SNPs33 traits1 studies0 positive · 0 negative

Mapping the proteo-genomic convergence of human diseases.

PubMed 34648354

0 evidence5K SNPs2K traits1 studies0 positive · 0 negative

Connected Genes (754)

DLEU1

deleted in lymphocytic leukemia 1

4 evidence368 SNPs0 traits0 studies4 positive · 0 negative

ESR1

estrogen receptor 1

This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a centr...

1 evidence278 SNPs0 traits0 studies1 positive · 0 negative

PCAT1

prostate cancer associated transcript 1

This gene produces a long non-coding RNA that promotes cell proliferation and is upregulated in prostate, colorectal, and other cancers. This RNA negatively regulates the BRCA2...

2 evidence244 SNPs0 traits0 studies1 positive · 1 negative

PPP1R3B-DT

PPP1R3B divergent transcript

2 evidence242 SNPs0 traits0 studies2 positive · 0 negative

SOX5

SRY-box transcription factor 5

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the c...

7 evidence240 SNPs0 traits0 studies4 positive · 3 negative

Connected SNPs (1,798)

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