Restless Legs

8K383110

Restless Legs Syndrome (RLS) is a neurological condition characterized by an uncontrollable urge to move the legs, often accompanied by uncomfortable sensations, especially during periods of rest or at night. Research shows that variations near genes involved in dopamine signaling and iron metabolism (like MEIS1, BTBD...

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SNP Stats

Mapped
383
Positive
203 (53.0%)
Negative
180 (47.0%)

Genome Matching (1)

Public Results (7,972)

NA11992

1000 Genomes Project · European · Human

347 of 368 SNPs with zeta at 5.228

99.9

NA18564

1000 Genomes Project · East Asian · Human

347 of 368 SNPs with zeta at 4.687

99.9

HG04131

1000 Genomes Project · South Asian · Human

347 of 368 SNPs with zeta at 4.559

99.9

HG03884

1000 Genomes Project · South Asian · Human

347 of 368 SNPs with zeta at 4.385

99.9

NA18991

1000 Genomes Project · East Asian · Human

347 of 368 SNPs with zeta at 4.190

99.9

NA18967

1000 Genomes Project · East Asian · Human

347 of 368 SNPs with zeta at 4.182

99.9

huDA2757

Personal Genome Project · European American · Human

188 of 368 SNPs with zeta at 4.166

99.9

Connected Traits (1)

restless legs syndrome

EFO_0004270

0 evidence399 SNPs1 traits0 studies0 positive · 0 negative

Connected Studies (10)

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.

PubMed 39024449

0 evidence15K SNPs829 traits1 studies0 positive · 0 negative

Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.

PubMed 38839884

0 evidence331 SNPs1 traits1 studies0 positive · 0 negative

Large genome-wide association study identifies three novel risk variants for restless legs syndrome.

PubMed 33239738

0 evidence25 SNPs1 traits1 studies0 positive · 0 negative

Connected Genes (152)

POLR1HASP

POLR1H antisense, pseudogene

1 evidence367 SNPs0 traits0 studies1 positive · 0 negative

PTPRD

protein tyrosine phosphatase receptor type D

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular proce...

16 evidence283 SNPs0 traits0 studies9 positive · 7 negative

DAB1

DAB adaptor protein 1

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain...

7 evidence249 SNPs0 traits0 studies3 positive · 4 negative

ASTN2

astrotactin 2

This gene encodes a protein that is expressed in the brain and may function in neuronal migration, based on functional studies of the related astrotactin 1 gene in human and mou...

1 evidence212 SNPs0 traits0 studies0 positive · 1 negative

CTNNA3

catenin alpha 3

This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are...

1 evidence208 SNPs0 traits0 studies0 positive · 1 negative

Connected SNPs (383)

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